Mass Spectral Libraries
Drogas, tóxicos y sus metabolitos para LC-MS
WileyMost of the CNS acting drugs (e.g. drugs of abuse) are lipophilic compounds which are excreted into urine mainly in metabolized form.
Información adicional
Common GC-MS screening, using comprehensive libraries with electron ionization spectra and sophisticated search algorithms, provides excellent screening results with the limitation of volatile and apolar compounds.
LCMSn screening with corresponding libraries can overcome these limitations, but up until now, all have mainly covered parent compounds.
Thus their applicability for urine screening is limited because most toxicologically relevant compounds are excreted into urine more or less exclusively as phase I and/or II metabolites.
The Maurer/Wissenbach/Weber LCMSn Library of Drugs, Poisons, and Their Metabolites provides a proven metabolite-based LCMSn screening methods and MS3 spectra of about 1,000 parent compounds and 2,700 of their metabolites. Detection of metabolites increases the sensitivity, detection window, and the selectivity, allows confirmation of the body passage, and finally, minimizes the risk of false negative LC-MS results possibly caused by ion suppression of the target analyte. Even the risk of false positive results can be reduced considering the metabolite patterns.
Características
Spectra: >10,000
Structures: 6,816
Toxicologically Relevant Compounds: 1,500
Metabolites/Artifacts: 3,000
Endogenous Molecules/Impurities: 50
Compound coverage can be searched at www.compoundsearch.com. Compound coverage includes:
- Alkaloid
- Anabolic
- Analgesic
- Anesthetic
- Anorectic
- Antagonist of benzodiazepines
- Anthelmintic
- Antiamebic
- Antianginal
- Antiarrhythmic
- Antiasthmatic
- Antibiotic
- Anticholinergic
- Anticoagulant
- Anticonvulsant
- Antidepressant
- Antidiabetic
- Antidiarrheal
- Antiemetic
- Antiestrogen
- Antigonadotropin
- Antihistamine
- Antihyperlipic
- Antihypertensive
- Antihypotensive
- Antiinflammatory
- Antilipemic
- Antimalarial
- Antimigraine
- Antimycotic
- Antineoplastic
- Antiparkinsonian
- Antirheumatic
- Antiseptic
- Antispasmodic
- Antitussive
- Aromatase inhibitor
- Benign prostatic hyperplasia drug
- Beta-Blocker
- Bronchodilator
- Ca Antagonist
- Cannabimimetic
- Cannabinoid
- Capillary protectant
- Cardiotonic
- ChE inhibitor for M. Alzheimer
- Chemical
- Chemotherapeutic
- Cholinergic
- Coronary dilator
- Dermatic
- Designer drug
- Diagnostic aid
- Diuretic
- Dopamine agonist
- Doping agent
- Emetic
- Endogenous biomolecule/impurity
- Expectorant
- Fungicide
- GABA-Antagonist
- Gestagen
- H2-Blocker
- Hemostatic
- Herbicide
- Hypnotic
- Immunosuppressant
- Incontinence drug
- Ingredient of black pepper
- Ingredient of cannabis
- Ingredient of nutmeg
- Ingredient of opium
- Insecticide
- Laxative
- Local anesthetic
- Muscle relaxant
- Mydriatic
- Neuroleptic
- Nicotine replacement therapeutic
- Nootropic
- Opioid antagonist
- Ovulation stimulant
- Parasympatholytic
- Parasympathomimetic
- Pesticide
- Potent analgesic
- Potent antitussive
- Preservative
- Psychedelic
- Rodenticide
- Rubber additive
- Rubefacient in pepper spray
- Sedative
- Selective estrogen receptor modulator
- Serotonin antagonist
- Softener
- Steroid
- Stimulant
- Sympatholytic
- Sympathomimetic
- Thrombocyte aggregation inhibitor
- Tocolytic
- Tranquilizer
- Tuberculostatic
- Ulcus therapeutic
- Uricosuric
- Urinary antiseptic
- Vasoconstrictor
- Vasodilator
- Virustatic
